FIP Bloodwork Interpretation

↓ A:G Ratio (<0.4 🚩)

🩸 Strongly supports FIP when combined with compatible clinical signs.

↑ Globulin (hyperglobulinemia)

🩸 The immune system produces large amounts of antibodies in response to the virus.

↓ Albumin (hypoalbuminemia)

🩸 Chronic inflammation and vascular damage reduce albumin levels.

↑ Bilirubin (hyperbilirubinemia)

🩸 Vasculitis, liver involvement, and inflammation can impair bilirubin clearance.

↓ RBC (non-regenerative anemia)

🩸 Chronic inflammation suppresses red blood cell production.

↓ Lymphocytes (lymphopenia)

🩸 FIP commonly causes lymphocyte depletion during systemic disease.

↑ Neutrophils (neutrophilia)

🩸 Reflects the intense inflammatory response triggered by infected macrophages.

‼️ Important Note ‼️ ⚠️ There is no single pathognomonic CBC or biochemistry result for FIP, but several findings strongly support the diagnosis when combined with clinical signs.

High Suspicion FIP:

🔸 Young age (<2 years)
🔸 Persistent fever
🔸 Weight loss/lethargy
🔸 Hyperglobulinemia
🔸 A:G ratio <0.4
🔸 Lymphopenia ± neutrophilia
🔸 Effusion or ocular/neurologic signs