FIP Bloodwork Interpretation

↓ A:G Ratio (<0.4 🚩)
🩸 Strongly supports FIP when combined with compatible clinical signs.
↑ Globulin (hyperglobulinemia)
🩸 The immune system produces large amounts of antibodies in response to the virus.
↓ Albumin (hypoalbuminemia)
🩸 Chronic inflammation and vascular damage reduce albumin levels.
↑ Bilirubin (hyperbilirubinemia)
🩸 Vasculitis, liver involvement, and inflammation can impair bilirubin clearance.
↓ RBC (non-regenerative anemia)
🩸 Chronic inflammation suppresses red blood cell production.
↓ Lymphocytes (lymphopenia)
🩸 FIP commonly causes lymphocyte depletion during systemic disease.
↑ Neutrophils (neutrophilia)
🩸 Reflects the intense inflammatory response triggered by infected macrophages.
‼️ Important Note ‼️ ⚠️ There is no single pathognomonic CBC or biochemistry result for FIP, but several findings strongly support the diagnosis when combined with clinical signs.

High Suspicion FIP:

  • 🔸 Young age (<2 years)
  • 🔸 Persistent fever
  • 🔸 Weight loss/lethargy
  • 🔸 Hyperglobulinemia
  • 🔸 A:G ratio <0.4
  • 🔸 Lymphopenia ± neutrophilia
  • 🔸 Effusion or ocular/neurologic signs